One problem with using only prescription drugs to quit smoking is that drugs focus primarily on the physical addiction to nicotine, and not the psychological dependence, in spite of the psychoactive effects.
Chantix and Zyban have been shown to help people quit, but you can improve your chances by combining these drugs with effective techniques for eliminating the psychological dependence, too.
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Besides Wellbutrin, another antidepressant, nortriptyline, has also been shown to help people quit, but it has not been FDA-approved as a medication to quit smoking, and is not usually prescribed because it has more severe side effects than other drugs that work about as well.
Other antidepressants such as Effexor (venlafaxine), Paxil (paroxetine), Prozac (fluoxetine), and Zoloft (sertraline) work by a different mechanism and have NOT been shown to help people quit smoking.
Anti-anxiety drugs have also been tested, under the theory that reducing anxiety would be helpful for people quitting. However, there is no evidence that anti-anxiety medication help people quit smoking, and these drugs are addictive and have their own side-effects.
None of these are good options to try. If you're going to try a prescription medication, stick with Zyban or Chantix, and be sure to couple it with a complete behavioral program, as well.